Apr 18 2017

LCKL 073 – Coenzyme A – The Power of It for Fat Loss, Physical Performance and Much More…

Co-Enzyme A is a critical enzyme that is needed to function the body as well as to assist in the production of Co-Enzyme Q10 and NADH. Learn about what you can do to increase your own level of Co-Enzyme A and what may be causing you to be deficient.

  • What Coenzyme A is;
  • Symptoms of Coenzyme A Deficiency;
  • Factors that deplete Coenzyme A in your body;
  • 9 Benefits of Coenzyme A;
  • Whether Coenzyme A supplementation is beneficial;
  • What type of Supplement is the most useful for increasing Coenzyme A in your body;
  • Increasing levels of Coenzyme A in the body.
What is Co-Enzyme A?Symptoms of CoA DeficiencyBenefitsWill Coenzyme A Supplementation be effective?How To Increase Levels of Co Enzyme A in the body...
  • Coenzyme A is a nonprotein chemical substance which is needed for the activation of many enzymes.
  • If there is not enough CoEnzyme A in the body, it will be unable to synthesize CoEnzyme Q10 or NADH.
  • It is naturally synthesized from Vitamin B5 (Pantothenic Acid). This Vitamin is able to be found in meats and vegetables so is provided in adequate quantities in the ketogenic diet.
  • Deficiencies of this nutrient is extremely rare but when it does occur, symptoms include:
    • Fatigue;
    • Muscle Soreness; and
    • Metabolic Disorders.
  • However, there are a number of factors which can deplete your body of Coenzyme A such as:
    • Exercise;
    • Toxic Metals; and
    • Environmental Toxins.

Lowers Stress Levels

  • It is vital to the production of hydrocortisone, which is the anti-stress hormone.
  • Therefore, a deficiency in CoA can result in depression, anxiety, irritability, fatigue, increased need for sleep and lowered immunity.
  • If you are overly stressed, Co A supplementation can be of benefit.

Increases Energy

  • CoA is required to metabolize fats, carbohydrates and proteins and is important for converting them into energy at a cellular level.
  • It is incredibly important for energy production due to the fact that it is a major part of the Krebs Energy Cycle within the cells.
  • A deficiency of this vitamin can block the energy cycle and lead to a host of metabolic disorders.
  • Co-enzyme A is classified as the ignition switch for the whole process of energy production and therefore a deficiency can lead to chronic fatigue syndrome.

Prevents Weight Gain

  • Having a deficiency in this enzyme will result in not only lack of energy therefore prevent you from exercising but will also stop the metabolism of fats, therefore causing the fats to accumulate.

Synthesizes Fatty Acids

  • Both CoA and its acyl-carrier protein are required for the synthesis of fatty acids.
  • Fatty acids are important components of many lipids, which are fat molecules that are essential for normal physiological function.
  • These essential fats include such substances as sphingolipids, which are important components of the myelin sheath which enhance nerve transmission, as well as phospholipids which are found in the cell membranes.

Helps with the Functioning of other Co-Enzymes

  • CoA is essential for the functioning of other important enzymes and coenzymes.
  • For instance, CoA is necessary to utilise Coenzyme Q10, as well as other important energy producing enzymes.
  • Without CoA, CoQ10 cannot perform its essential tasks of protecting against Heart Disease, Muscular Dystrophies, Parkinson’s Disease, Cancer, Diabetes and HIV.

Helps Reduce Acne

  • Research has shown that CoA supplementation can actually help to reduce the risk of and/or treat the occurrence of acne.
  • A study was conducted by Dr Leung, who found that acne breakouts are observed when the body fails to produce enough Coenzyme A. Therefore, the body fails to break down the fatty acids that are responsible for the production of sebum.
  • Deficiency in CoA has been linked to the inability to break down the fatty acids and also poor synthesis of sex hormones.
  • This particular study found that supplementation with Co A was able to resolve acne over a few week period and this lasted for over 6 months.

Helps in the Production of Various Hormones and Vitamins

  • Coenzyme A is required to transform cholesterol into all kinds of hormones.
  • It is required to help with the production of Vitamin D.
  • Important for the synthesis of the neurotransmitter acetylcholine.
  • Important for the synthesis of the hormone melatonin.
  • Important for the synthesis of haemoglobin.

Assists in the Metabolism of Drugs and Toxins by the liver

Important for Acetylation Reactions

  • Protein acetylation affects the 3 dimensional structure of proteins, potentially altering their function.
  • This appears to play a role in cell division and DNA replication.
  • No, supplementing with CoEnzyme A alone will not be effective.
  • Coenzyme A is produced within the cells.
  • The digestive process will simply break down the Coenzyme A back into its components when it enters the bloodstream.
  • It is much more effective to instead take a supplement that includes its derivatives Vitamin B5 and B6/Folate (conversion of homocysteine to cysteine).
  • However, there is a supplement known as Pantethine (which will be discussed in next weeks episode) which has been found to be a much more effective way of increasing your Co A levels in your body as well as a whole host of other benefits. Make sure you listen out for next Wednesdays episode to hear more about that.
  • The best way to increase your level of CoA in the body is to ensure that you are consuming

sufficient Vitamin B5 or Pantothenic Acid.

  • Take a supplement of Pantethine, which is the active form of Vitamin B5.
  • Consume foods rich in Vitamin B5 such as:
    • Chicken Livers;
    • Sunflower Seeds;
    • Salmon;
    • Avocados;
  • As you can see these top foods are ones we do recommend on the ketogenic or low carb diet.
  • Decrease the level of toxins you are subjected to as environmental and nutritional toxins can deplete your body of high levels of Coenzyme A.
  • If you are a heavy exerciser, make sure you supplement with Pantethine as exercise can also deplete your body of this vital enzyme.
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Please note that this information is not intended for medical purposes or to replace the advice of your medical practitioner. It is for informational purposes only to help guide you on your journey towards optimal wellness.


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